DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q6P3S1_2001383 MC57022 A0A835ZVZ7_57022 1-213 159-371 1.0 0.53 1.0 0.53 0.53 1.0 92.9
P94692_2000554 MC56844 A0A2M6YGI6_56844 3-208 1-205 0.81 1.0 0.8 0.99 0.99 0.92 62.6
Q9XB21_2000315 MC56824 A0A7Y2UFG1_56824 1-90 1-90 1.0 0.98 0.97 0.95 0.95 0.99 50.0
Q3ACS3_2001407 MC5671 X0ZES5_5671 1-52 1-52 0.9 0.98 0.88 0.96 0.96 0.9 59.6
Q63Y17_2000045 MC56584 A0A7U8HCL8_56584 15-196 2-183 0.86 0.99 0.86 0.99 0.99 0.94 100.0
P33186_2000739 MC56510 Q9S9E4_56510 2-230 1-236 0.91 1.0 0.89 0.95 0.95 0.9 95.7
P9WHJ3_2000610 MC56470 A0A7V9JY04_56470 1-60 18-77 1.0 0.7 1.0 0.7 0.7 1.0 63.3
Q96FI4_2000055 MC56467 A0A835ZWI0_56467 1-125 2-126 1.0 0.38 1.0 0.38 0.38 0.99 88.8
Q2RW81_2001600 MC56452 A0A180FR20_56452 7-96 1-91 0.94 1.0 0.89 0.94 0.94 0.88 29.6
O97148_2000382 MC56451 A0A232FJN0_56451 5-159 19-157 0.82 0.88 0.51 0.59 0.59 0.45 21.9
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.