DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q8YZH5_2001491 MC5748 A0A3B8I3H4_5748 1-86 83-177 1.0 0.54 0.48 0.27 0.27 0.52 23.5
P94837_2001494 MC57387 A0A1K1RSE9_57387 1-109 1-100 0.84 0.95 0.43 0.51 0.51 0.44 13.9
Q15642_2001089 MC57356 A0A067D1V4_57356 1-277 19-325 0.99 0.9 0.85 0.71 0.71 0.8 12.9
A0A0H2Z989_2001542 MC57356 A0A533U9B3_57356 2-229 1-177 0.95 0.68 0.31 0.28 0.28 0.52 9.7
P04191_2000633 MC573 A0A819LKY1_573 1-242 13-254 1.0 0.9 0.99 0.9 0.9 0.96 70.6
Q5F5I0_2001452 MC57275 A0A378WCZ0_57275 1-58 136-193 1.0 0.3 0.98 0.3 0.3 0.98 94.8
Q16254_2000270 MC57242 A0A553N9I2_57242 4-106 3-107 0.97 0.61 0.92 0.57 0.57 0.95 57.1
Q180S3_2000015 MC57188 E5Y1G5_57188 4-232 2-231 0.99 0.68 0.98 0.68 0.68 0.93 50.0
O54790_2001195 MC5710 A0A6B0RVA1_5710 1-41 53-93 1.0 0.25 1.0 0.25 0.25 1.0 80.4
P62697_2000725 MC57082 A0A2K5XG27_57082 2-87 1-86 0.98 1.0 0.97 1.0 1.0 0.98 91.8
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.