DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

CATH Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
3.40.1720 MC2046 A0A285HFV6_2046 11-99 87-175 0.9 0.48 0.47 0.28 0.28 0.51 8.0
3.90.770 MC20279 A0A6N2N4E5_20279 1-206 75-397 1.0 0.81 0.98 0.51 0.51 0.97 42.5
3.30.20 MC20275 A0A7S4RWD3_20275 1-56 1-65 1.0 0.39 0.53 0.19 0.19 0.48 18.5
3.10.510 MC20254 A0A2I8QWU0_20254 1-76 5-80 1.0 0.84 0.85 0.72 0.72 0.76 85.5
3.90.340 MC20246 Q9Z0J4_20246 6-158 2-361 0.96 0.91 0.91 0.37 0.37 0.89 41.1
3.40.1560 MC2024 A0A059WUB8_2024 10-105 3-103 0.82 0.94 0.48 0.51 0.51 0.45 11.1
3.30.2340 MC20081 A0A4U9II06_20081 1-136 3-138 1.0 0.77 0.99 0.76 0.76 0.98 82.3
2.30.210 MC19939 R7GAB4_19939 8-67 25-122 0.88 0.65 0.52 0.26 0.26 0.56 7.1
3.30.1810 MC19934 E1JBX7_19934 2-127 7-132 0.99 0.93 0.9 0.85 0.85 0.81 80.9
1.10.700 MC19548 A0A1A8TJZ6_19548 1-100 3-102 1.0 0.95 0.98 0.93 0.93 0.96 54.0
Legend
  • Agreement between CATH Folds and DPCstruct Metacluster Domains:
  • CATH Fold: CATH fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.