DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

CATH Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
1.10.1280 MC21471 A0A5B7CRV4_21471 2-224 25-247 1.0 0.6 0.99 0.6 0.6 0.95 74.8
1.10.1490 MC21470 A0A7J4IGD0_21470 4-57 2-66 0.87 0.46 0.53 0.26 0.26 0.5 18.4
1.10.1710 MC21375 A0A1S1X770_21375 19-112 2-94 0.82 0.99 0.77 0.94 0.94 0.88 67.3
4.10.480 MC21263 A0A4R5EGL8_21263 9-79 1-71 0.9 0.58 0.89 0.57 0.57 0.89 78.8
1.10.4080 MC212 A0A3M0JBX9_212 3-344 2-342 0.96 0.99 0.94 0.97 0.97 0.9 51.7
1.10.4060 MC2092 A0A377UW09_2092 1-78 1-82 0.96 0.64 0.51 0.34 0.34 0.56 25.8
3.20.10 MC20763 L5LGE1_20763 2-174 124-296 0.99 0.57 0.99 0.57 0.57 0.98 89.0
3.10.660 MC2068 A0A7M2YV67_2068 5-74 20-81 0.9 0.57 0.55 0.42 0.42 0.54 13.8
4.10.1080 MC20633 A0A7V6B6E7_20633 9-122 4-115 0.9 0.97 0.57 0.63 0.63 0.75 47.3
3.30.1110 MC20590 A0A2A3E0I8_20590 1-63 21-140 1.0 0.36 0.98 0.19 0.19 0.96 36.6
Legend
  • Agreement between CATH Folds and DPCstruct Metacluster Domains:
  • CATH Fold: CATH fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.