DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

CATH Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
1.10.4200 MC19546 A0A1I3FHC1_19546 1-221 31-317 1.0 0.85 0.81 0.55 0.55 0.66 20.8
1.10.1750 MC19534 A0A2P7SSF1_19534 2-87 87-158 0.9 0.45 0.41 0.28 0.28 0.53 17.0
1.10.440 MC1952 A0A7C5X945_1952 8-131 14-128 0.9 0.82 0.58 0.57 0.57 0.5 17.9
1.10.3500 MC19489 A0A370RP95_19489 1-259 8-397 1.0 0.75 0.95 0.48 0.48 0.9 39.6
1.10.950 MC19322 A0A6F9AXN3_19322 1-64 34-97 1.0 0.66 0.95 0.64 0.64 0.93 54.6
2.40.410 MC19096 A0A1A0K1K7_19096 1-127 85-211 1.0 0.6 0.95 0.57 0.57 0.9 51.9
1.10.1630 MC18999 A0A6H5IZW9_18999 3-59 1-55 0.97 0.32 0.47 0.18 0.18 0.63 16.3
6.20.30 MC18924 A0A520PPW7_18924 3-66 35-94 0.94 0.61 0.23 0.17 0.17 0.58 11.4
1.20.1130 MC18911 A0A2G2X906_18911 1-737 9-313 0.99 0.97 0.32 0.74 0.74 0.6 33.3
1.10.3870 MC18402 A0A6I1Z6S2_18402 1-116 24-202 1.0 0.61 0.81 0.34 0.34 0.68 20.0
Legend
  • Agreement between CATH Folds and DPCstruct Metacluster Domains:
  • CATH Fold: CATH fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.