DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

CATH Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
1.10.640 MC21986 A0A6P7JCB2_21986 94-510 1-417 0.82 0.96 0.81 0.96 0.96 0.88 73.3
1.20.1080 MC21954 A0A7J6ZAX6_21954 3-225 2-223 0.98 1.0 0.97 0.99 0.99 0.95 66.3
3.60.40 MC21935 A0A161R289_21935 33-356 24-340 0.91 0.91 0.14 0.14 0.14 0.0 9.8
1.10.2010 MC21912 D0EZP2_21912 2-78 20-95 0.99 0.8 0.85 0.71 0.71 0.74 41.5
1.10.239 MC21805 A0A2D4C2G4_21805 4-93 2-91 0.96 0.49 0.77 0.42 0.42 0.69 22.3
3.30.2380 MC21766 A0A6B0RJJ8_21766 2-142 1-144 0.84 0.99 0.83 0.95 0.95 0.87 87.5
3.30.1870 MC2169 A0A383RB00_2169 2-65 40-106 0.94 0.63 0.92 0.6 0.6 0.93 44.7
3.40.1480 MC21599 A0A2D6KWG5_21599 22-183 215-371 0.88 0.42 0.81 0.41 0.41 0.77 42.3
3.90.570 MC21565 A0A803T1X3_21565 5-95 1-91 0.93 1.0 0.9 0.97 0.97 0.91 64.8
3.90.700 MC2156 A0A2K6T7R4_2156 1-104 19-122 1.0 0.52 1.0 0.52 0.52 1.0 98.0
Legend
  • Agreement between CATH Folds and DPCstruct Metacluster Domains:
  • CATH Fold: CATH fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.