DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q28JX0_2000994 MC7756 A0A845WXV2_7756 8-105 3-101 0.87 0.97 0.83 0.92 0.92 0.83 41.4
Q5SIT5_2001562 MC7710 A0A7J8CPU4_7710 4-96 44-138 0.94 0.63 0.69 0.47 0.47 0.89 17.8
P58547_2000746 MC7660 A0A231WC49_7660 1-46 1-53 0.9 0.37 0.59 0.25 0.25 0.55 10.7
Q8GXX0_2000080 MC7649 A0A5A7PVL0_7649 1-101 22-122 1.0 0.76 1.0 0.76 0.76 0.99 84.1
P29372_2000011 MC7641 A0A5F9DFR9_7641 1-157 13-169 1.0 0.74 0.98 0.72 0.72 0.97 88.5
Q9UMX1_2001237 MC7638 A0A6P8ZBC4_7638 5-235 1-231 0.98 0.49 0.97 0.49 0.49 0.96 70.5
Q43088_2000749 MC7630 W9RH21_7630 2-148 25-147 0.86 0.54 0.56 0.43 0.43 0.63 18.1
Q9XGU3_2000685 MC7604 A0A3R7AZL6_7604 46-291 2-227 0.84 0.95 0.71 0.86 0.86 0.75 33.8
Q96FI4_2000049 MC7594 A0A811Y4X2_7594 1-24 88-111 1.0 0.16 0.99 0.16 0.16 1.0 91.6
Q91V82_2000440 MC7591 A0A423TPE8_7591 1-35 49-84 1.0 0.18 0.85 0.17 0.17 0.86 30.5
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.