DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P29468_2000113 MC22675 W0T6X7_22675 1-197 29-225 1.0 0.53 1.0 0.53 0.53 0.99 83.2
A0A0H2UQV3_2000486 MC22623 F2CDD3_22623 1-124 6-129 1.0 0.96 1.0 0.96 0.96 1.0 79.0
A1X1V8_2000404 MC22595 A1X1V8_22595 1-39 13-51 1.0 0.43 1.0 0.43 0.43 1.0 100.0
P02829_2001394 MC22549 A0A1Y6LJD5_22549 1-85 43-127 1.0 0.3 1.0 0.3 0.3 1.0 85.8
P41148_2000908 MC22549 A0A095ASK3_22549 1-133 148-279 1.0 0.46 0.98 0.46 0.46 0.95 50.3
A0A380YR22_2001284 MC22499 Q64RD4_22499 18-167 1-150 0.9 1.0 0.9 1.0 1.0 0.94 97.3
P00949_2000940 MC22469 A0A5F7ZI92_22469 1-113 109-221 1.0 0.26 1.0 0.26 0.26 1.0 99.1
O27001_2000515 MC2242 S4RUA8_2242 6-105 129-226 0.82 0.42 0.27 0.14 0.14 0.53 8.5
A1JJJ6_2001283 MC22390 A0A4U9UGK0_22390 2-131 1-133 0.99 0.93 0.97 0.89 0.89 0.96 78.1
Q56026_2000965 MC22385 A0A379SQZ3_22385 1-170 2-168 0.85 0.99 0.82 0.97 0.97 0.91 70.5
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.