DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P0ABR1_2000700 MC801 A0A0K0H923_801 4-78 2-76 0.93 0.99 0.91 0.96 0.96 0.9 85.3
Q8JFY9_2000445 MC7993 A0A6A4T1F1_7993 1-279 32-309 0.98 0.9 0.97 0.89 0.89 0.94 56.2
P9WGP5_2000713 MC7919 A0A7C4YTL1_7919 1-124 1-139 1.0 0.58 0.92 0.49 0.49 0.84 32.3
Q69YH5_2001583 MC7900 A0A485L3L5_7900 4-33 14-43 0.91 0.16 0.37 0.11 0.11 0.68 16.6
Q2YQE0_2001190 MC79 A0A2E2J5R2_79 1-99 1-99 0.99 1.0 0.98 0.99 0.99 0.96 55.5
Q6D5X8_2001641 MC7877 A0A484LQG5_7877 8-87 30-113 0.92 0.74 0.39 0.32 0.32 0.53 14.6
P18858_2001217 MC7851 A0A3Q0HBI9_7851 1-272 39-310 1.0 0.81 0.98 0.8 0.8 0.96 72.0
P53396_2000152 MC7848 Q4STH3_7848 2-145 420-563 0.99 0.23 0.99 0.23 0.23 0.99 88.8
P37590_2001522 MC784 A0A5K1IBI4_784 2-84 79-162 0.98 0.51 0.69 0.39 0.39 0.63 5.8
U5WZP7_2001414 MC7823 F8DXJ2_7823 28-202 2-174 0.87 0.99 0.81 0.93 0.93 0.82 48.2
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.