DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
O05391_2001388 MC33757 A0A3E0QQU2_33757 1-76 87-165 1.0 0.48 0.88 0.42 0.42 0.81 23.7
P24289_2000931 MC3373 A0A545UYU1_3373 1-263 10-272 1.0 0.92 0.99 0.92 0.92 0.98 74.1
P07358_2000520 MC33701 A0A7J7ZSV8_33701 1-51 4-54 1.0 0.94 0.99 0.93 0.93 1.0 84.3
O73972_2000162 MC33674 C0BDV8_33674 1-97 87-189 0.92 0.54 0.89 0.5 0.5 0.84 38.8
P17452_2000552 MC33640 P17452_33640 22-218 1-197 0.9 1.0 0.9 1.0 1.0 0.96 100.0
P48845_2000975 MC33618 A0A2N9L2I8_33618 24-198 22-131 0.88 0.4 0.42 0.31 0.31 0.51 17.4
Q9NWZ3_2000050 MC33572 A0A4U1EGQ4_33572 1-103 4-106 1.0 0.71 1.0 0.71 0.71 1.0 96.1
Q03456_2000111 MC33551 A0A0A2VTP8_33551 1-49 84-132 1.0 0.36 0.96 0.35 0.35 0.95 48.9
Q96RN5_2000766 MC33540 A0A2M4BBR7_33540 1-65 2-66 0.88 0.97 0.85 0.93 0.93 0.89 40.0
Q92PM3_2001492 MC33528 A0A182D582_33528 3-122 1-120 0.94 0.99 0.92 0.97 0.97 0.9 48.7
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.