DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P08581_2000539 MC34207 A0A452T624_34207 2-49 77-124 0.98 0.36 0.95 0.36 0.36 0.95 85.4
Q82ZV0_2000827 MC3410 A0A0B0HXU1_3410 15-132 13-118 0.89 0.9 0.35 0.38 0.38 0.51 11.0
Q6NIK0_2001608 MC3410 A0A1H9VKW6_3410 5-88 13-107 0.93 0.7 0.47 0.34 0.34 0.54 10.5
G1TG89_2000459 MC34049 A0A673VT31_34049 3-128 1-126 0.98 1.0 0.98 1.0 1.0 0.99 100.0
Q183N4_2001392 MC34017 A0A540L087_34017 1-94 1-63 0.96 0.98 0.38 0.5 0.5 0.4 6.3
Q4DQ60_2001051 MC34017 A0A061JAV4_34017 1-58 8-65 1.0 0.76 0.99 0.76 0.76 1.0 94.8
Q9S581_2000273 MC3392 A0A2A2KF66_3392 1-89 67-159 0.99 0.42 0.59 0.28 0.28 0.62 12.2
Q38720_2001055 MC33911 W9RB99_33911 1-133 29-161 1.0 0.77 1.0 0.77 0.77 0.99 75.9
Q8ZKW0_2000567 MC33902 A0A1T4LMI8_33902 1-120 1-120 0.86 0.99 0.84 0.96 0.96 0.77 37.5
Q8VRA1_2001520 MC3379 B3Y1S4_3379 17-149 1-133 0.89 1.0 0.89 1.0 1.0 0.97 98.4
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.