DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P20163_2000420 MC35386 A0A1J5IPZ6_35386 1-125 2-128 0.84 0.98 0.68 0.78 0.78 0.79 24.0
Q9Y248_2000229 MC35370 A0A6A4TDI9_35370 1-61 5-65 1.0 0.34 0.99 0.33 0.33 1.0 85.2
Q5B6T5_2001505 MC35364 C6HBF7_35364 1-85 7-92 1.0 0.8 0.99 0.79 0.79 0.99 73.2
P0ADE4_2001282 MC35303 A0A3S4ICK9_35303 1-86 27-112 1.0 0.52 1.0 0.51 0.51 1.0 86.0
Q9K6V7_2000397 MC353 A0A1I1BDI8_353 19-138 1-120 0.81 0.99 0.79 0.96 0.96 0.84 35.8
P42981_2000611 MC35185 A0A804N154_35185 1-188 1-127 0.81 0.91 0.34 0.51 0.51 0.35 8.9
P25080_2000005 MC35185 A0A7C1T3B2_35185 1-179 5-183 1.0 0.98 0.99 0.97 0.97 0.98 65.3
Q8NBZ7_2000148 MC35185 T1J4U0_35185 1-239 13-251 1.0 0.87 1.0 0.87 0.87 1.0 86.1
Q9HL27_2001377 MC35058 A0A534JDG6_35058 1-158 59-219 1.0 0.46 0.97 0.44 0.44 0.9 45.3
P49327_2001386 MC35035 A0A7R9F1R6_35035 1-27 52-78 1.0 0.21 0.95 0.21 0.21 0.99 29.6
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.