DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P18054_2000858 MC34997 A0A7J7TX21_34997 36-451 1-406 0.85 1.0 0.82 0.98 0.98 0.86 72.6
P04063_2000937 MC34995 A0A0E0M208_34995 1-57 18-74 1.0 0.73 0.99 0.72 0.72 0.99 61.4
P0AD61_2000800 MC34978 A0A813G145_34978 1-98 141-239 1.0 0.24 0.96 0.24 0.24 0.91 41.4
P04062_2000031 MC34978 S9XHJ2_34978 1-354 15-368 1.0 0.93 1.0 0.93 0.93 1.0 92.3
Q7SIG5_2000673 MC34978 A0A0G4M6F8_34978 1-339 34-373 0.98 0.91 0.97 0.9 0.9 0.93 63.6
P19483_2000654 MC34967 A0A813YTP9_34967 1-71 24-94 1.0 0.52 1.0 0.52 0.52 1.0 91.5
Q04759_2000892 MC34963 A0A1A8CNP8_34963 1-53 35-87 1.0 0.57 1.0 0.57 0.57 1.0 77.3
Q08685_2001466 MC3488 A0A382DQ55_3488 1-97 1-60 0.94 0.87 0.37 0.51 0.51 0.45 10.2
Q16543_2000744 MC34828 E0VJZ0_34828 2-201 38-240 1.0 0.83 0.95 0.79 0.79 0.97 59.1
Q8A2T3_2001352 MC34798 A0A2T5Z0K1_34798 2-136 4-136 0.98 0.96 0.75 0.74 0.74 0.69 16.1
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.