DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q9I530_2001244 MC51816 A0A812NU11_51816 2-321 54-381 0.98 0.86 0.95 0.82 0.82 0.89 42.0
Q9Y8U3_2000367 MC51797 A0A7C2TJJ2_51797 2-148 7-155 0.98 0.91 0.93 0.86 0.86 0.84 30.6
Q8N668_2001607 MC51752 A0A1E1XV62_51752 8-108 1-102 0.94 0.77 0.91 0.74 0.74 0.86 42.1
A0A0H3MCR9_2001621 MC51752 A0A7C3LKT3_51752 2-166 25-190 0.99 0.78 0.46 0.38 0.38 0.71 13.7
O00834_2001397 MC51739 A0A2A9M1X6_51739 1-91 31-121 1.0 0.3 0.98 0.29 0.29 0.96 57.1
P14565_2001465 MC51710 A0A0M9XPK9_51710 4-257 3-328 0.83 0.99 0.56 0.53 0.53 0.51 15.1
Q3SZX5_2000686 MC51704 A0A670IIC7_51704 1-110 18-127 1.0 0.82 1.0 0.81 0.81 1.0 87.2
Q8TX89_2000163 MC51680 A0A2N3S7S6_51680 3-109 46-142 0.95 0.67 0.49 0.4 0.4 0.51 13.3
P9WF25_2000569 MC51669 A0A6J6PPH5_51669 1-38 1-38 1.0 0.47 0.98 0.47 0.47 0.99 60.5
P44741_2001485 MC51665 A0A2V0PFY0_51665 4-310 1-333 0.98 1.0 0.89 0.84 0.84 0.72 20.5
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.