DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
A0A6A5PX22_2000471 MC59998 Q752S0_59998 12-167 2-153 0.91 0.96 0.79 0.85 0.85 0.78 49.3
P0A6Y5_2000743 MC59971 A0A377LAQ0_59971 1-178 3-180 0.81 0.99 0.8 0.98 0.98 0.89 100.0
Q8U1K3_2000621 MC59966 A0A3N1VQ59_59966 9-176 1-167 0.8 1.0 0.77 0.96 0.96 0.7 36.0
P64496_2000974 MC59957 A0A078KVF4_59957 4-54 131-182 0.85 0.17 0.62 0.16 0.16 0.71 11.5
Q9DC50_2000227 MC59957 A0A182J9G7_59957 2-217 86-301 0.99 0.69 0.98 0.68 0.68 0.94 41.6
P96719_2000926 MC59928 A0A430HQT9_59928 3-258 5-279 0.98 0.99 0.89 0.83 0.83 0.77 30.9
Q13888_2000544 MC59896 F4X4X4_59896 1-188 9-196 1.0 0.96 1.0 0.96 0.96 0.98 54.2
P44882_2000691 MC59839 A0A2X3ERR9_59839 2-163 10-172 0.95 0.9 0.93 0.87 0.87 0.87 48.1
O43395_2000613 MC5978 L8Y6R2_5978 1-79 1-79 1.0 0.41 0.99 0.41 0.41 0.99 100.0
Q9HY15_2001482 MC59764 A0A6G1A2W7_59764 9-113 3-104 0.93 0.98 0.8 0.86 0.86 0.75 13.2
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.