DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q9X1P6_2000641 MC23650 A0A1T4L341_23650 9-193 2-183 0.92 0.99 0.87 0.95 0.95 0.85 25.1
Q9UHD1_2001618 MC23615 G3RLV2_23615 1-68 1-68 1.0 0.85 0.99 0.84 0.84 1.0 94.1
Q9Y692_2000310 MC23613 A0A3Q3AMI0_23613 1-90 51-140 1.0 0.61 0.99 0.61 0.61 0.99 78.8
Q60770_2001175 MC23571 A0A556U061_23571 23-547 1-497 0.91 1.0 0.8 0.93 0.93 0.79 57.5
P35505_2000888 MC2355 A0A2T9Z5G0_2355 1-298 57-354 1.0 0.84 0.99 0.84 0.84 0.97 66.1
Q9SZ69_2001155 MC23536 A0A0D9WVY6_23536 1-51 111-161 1.0 0.31 0.94 0.3 0.3 0.97 56.8
Q970S6_2000159 MC23498 A0A7J2VD64_23498 10-175 1-166 0.95 1.0 0.94 0.99 0.99 0.93 59.0
Q8IWU9_2000896 MC23491 A0A6A4TAX3_23491 13-289 2-278 0.81 1.0 0.81 0.99 0.99 0.95 82.6
Q99ZW2_2001500 MC2333 Q99ZW2_2333 11-223 2-214 0.93 0.99 0.93 0.99 0.99 0.96 100.0
Q8U193_2000806 MC23222 A0A7J2N050_23222 1-182 47-222 0.99 0.79 0.93 0.77 0.77 0.9 61.5
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.