DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q9SLP6_2000899 MC41904 A0A6P5ZX16_41904 1-157 81-237 0.99 0.66 0.99 0.66 0.66 0.99 82.8
P77398_2000023 MC4186 A0A811CQ44_4186 2-199 1-198 0.99 1.0 0.99 1.0 1.0 0.98 75.2
Q9WZC3_2000665 MC41847 A0A429Z8E6_41847 1-110 3-132 0.94 0.56 0.54 0.32 0.32 0.48 4.3
Q5KVB6_2001255 MC41822 A0A063YJV6_41822 1-114 31-144 1.0 0.62 1.0 0.62 0.62 1.0 100.0
P25114_2000503 MC41802 S9XGK8_41802 1-190 16-205 1.0 0.92 1.0 0.91 0.91 0.99 75.2
P66881_2000555 MC41773 A0A318NY94_41773 19-246 2-229 0.91 0.99 0.91 0.99 0.99 0.91 81.5
Q9BVM4_2000798 MC41596 A0A7R9KWZ4_41596 1-137 1-126 0.91 1.0 0.81 0.97 0.97 0.89 37.2
P24613_2001232 MC41540 A0A803QDD0_41540 1-103 41-143 1.0 0.65 0.99 0.64 0.64 0.97 54.3
P82194_2000635 MC41538 A0A803M0W3_41538 8-115 1-108 0.93 1.0 0.93 0.99 0.99 0.97 95.3
O05403_2000222 MC41528 R7G731_41528 1-204 1-205 0.97 1.0 0.89 0.91 0.91 0.8 29.1
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.