DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P15640_2001030 MC41105 A0A2Z7A1J0_41105 1-102 1-102 1.0 0.3 0.99 0.3 0.3 0.98 69.6
Q8YFD6_2000387 MC40911 G7Y076_40911 10-316 2-310 0.92 1.0 0.91 0.98 0.98 0.9 40.1
P77072_2000057 MC40874 A0A7C1FVU5_40874 1-127 30-156 0.96 0.8 0.86 0.73 0.73 0.81 24.2
Q92922_2000142 MC40866 A0A368GFF7_40866 1-59 63-121 1.0 0.31 1.0 0.31 0.31 1.0 79.6
O35987_2000814 MC40716 A0A5K1U6D6_40716 5-76 113-184 0.95 0.38 0.92 0.38 0.38 0.94 68.0
Q830E8_2000870 MC40694 A0A5N1I7L4_40694 2-74 7-72 0.99 0.65 0.79 0.59 0.59 0.75 24.3
Q9K2N0_2000669 MC40686 A0A6B7PW49_40686 2-226 1-225 0.98 1.0 0.98 1.0 1.0 0.99 100.0
Q8IEU2_2001004 MC40670 A0A811GMX0_40670 1-82 22-102 0.94 0.72 0.65 0.53 0.53 0.63 8.1
Q95211_2001188 MC40670 A0A811GMX0_40670 18-105 30-112 0.84 0.74 0.4 0.38 0.38 0.5 7.8
P26446_2000755 MC4061 A0A7J7G9U8_4061 2-215 8-223 1.0 0.93 0.98 0.91 0.91 0.95 55.5
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.