DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q8DTU0_2000182 MC47839 A0A077ZFN7_47839 1-119 7-125 1.0 0.67 0.99 0.67 0.67 0.98 68.9
O43524_2001512 MC4782 A0A412J3G4_4782 1-24 1-24 1.0 0.1 0.45 0.08 0.08 0.85 20.8
A0QX93_2000695 MC47772 A0A0U1DEG4_47772 64-495 1-432 0.86 1.0 0.85 0.99 0.99 0.88 92.5
Q8XCU6_2000605 MC47764 A0A2E4HNG4_47764 9-86 2-78 0.81 0.99 0.76 0.93 0.93 0.79 32.0
X1WB74_2001298 MC47753 A0A183N7F0_47753 17-106 106-200 0.83 0.45 0.49 0.29 0.29 0.52 9.8
P01006_2001134 MC47730 N4V0H3_47730 3-92 2-74 0.84 0.96 0.4 0.53 0.53 0.41 12.9
P74881_2000452 MC47645 A0A340X8E8_47645 1-217 75-296 1.0 0.45 0.98 0.43 0.43 0.92 47.7
Q47108_2001191 MC47565 A0A3D5MC75_47565 2-195 24-217 0.98 0.89 0.96 0.87 0.87 0.9 58.2
P46849_2000950 MC47350 A0A2C5SCQ1_47350 1-59 77-135 1.0 0.44 1.0 0.44 0.44 1.0 98.3
P06762_2001027 MC47277 F6U7V2_47277 1-210 2-211 0.99 0.9 0.99 0.9 0.9 0.99 70.9
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.