DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

CATH Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
1.10.3570 MC6804 A0A811X7M9_6804 3-176 2-183 0.98 0.62 0.86 0.54 0.54 0.74 25.6
3.30.2350 MC6791 A0A3C0PB18_6791 1-163 3-167 0.81 0.76 0.76 0.7 0.7 0.7 35.1
1.10.1330 MC6764 A0A2D5M9N0_6764 6-57 75-127 0.87 0.41 0.81 0.39 0.39 0.83 39.6
1.20.1070 MC6762 A0A517YXC7_6762 22-267 57-282 0.91 0.77 0.39 0.36 0.36 0.0 11.9
2.40.40 MC6727 A0A3S5D9H7_6727 1-65 132-198 1.0 0.33 0.88 0.3 0.3 0.82 27.9
3.30.2410 MC6716 A0A2A2F927_6716 2-96 6-99 0.98 0.81 0.57 0.5 0.5 0.54 12.2
4.10.1110 MC6704 A0A1B0CGD3_6704 11-86 3-89 0.88 0.46 0.3 0.16 0.16 0.56 16.0
3.60.70 MC6703 A0A1D9Q2E5_6703 4-306 3-207 0.84 0.97 0.4 0.67 0.67 0.4 22.5
2.40.155 MC6696 A0A2D3HHT6_6696 1-206 10-125 0.97 0.91 0.13 0.19 0.19 0.0 7.4
2.70.20 MC6696 A0A4S4LNU7_6696 16-117 2-111 0.84 0.98 0.28 0.29 0.29 0.0 6.9
Legend
  • Agreement between CATH Folds and DPCstruct Metacluster Domains:
  • CATH Fold: CATH fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.