DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

CATH Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
4.10.240 MC6687 A0A1G4KHQ9_6687 1-34 123-154 1.0 0.17 0.87 0.17 0.17 0.87 41.1
1.20.930 MC6685 A0A0C9LZQ1_6685 4-136 96-228 0.97 0.25 0.94 0.25 0.25 0.89 40.6
2.80.10 MC6685 A0A821B8V7_6685 4-154 5-188 0.97 0.44 0.93 0.35 0.35 0.86 54.8
1.25.10 MC6685 A0A821B8V7_6685 1-104 190-381 0.99 0.46 0.88 0.23 0.23 0.8 32.2
1.10.40 MC6677 A0A6A5KSZ2_6677 1-61 154-214 0.98 0.26 0.96 0.26 0.26 0.94 90.1
1.10.1580 MC6677 A0A7C1F2N2_6677 1-92 98-189 0.99 0.47 0.96 0.46 0.46 0.89 35.8
3.40.1030 MC6677 A8IGD6_6677 4-241 5-212 0.91 0.97 0.19 0.22 0.22 0.0 15.6
2.60.175 MC6676 A0A644U2E2_6676 1-259 7-179 0.98 0.83 0.25 0.3 0.3 0.0 9.7
6.10.10 MC6657 A0A350X1L3_6657 1-56 1-56 1.0 0.98 0.97 0.95 0.95 0.96 64.2
1.10.30 MC6645 A0A7E4RTT8_6645 1-52 1-52 0.98 0.81 0.88 0.75 0.75 0.86 19.2
Legend
  • Agreement between CATH Folds and DPCstruct Metacluster Domains:
  • CATH Fold: CATH fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.