DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

CATH Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
3.40.1830 MC14882 A0A523YHZ8_14882 4-149 2-117 0.81 0.97 0.42 0.57 0.57 0.44 12.5
3.40.1340 MC14882 A0A499V551_14882 1-131 24-181 0.96 0.85 0.52 0.4 0.4 0.44 9.6
1.10.3790 MC14875 A0A0K5JL59_14875 3-128 1-126 0.95 0.99 0.87 0.91 0.91 0.89 53.9
3.90.580 MC14691 A0A7C6KV06_14691 10-95 2-90 0.84 0.38 0.69 0.32 0.32 0.66 25.2
1.10.230 MC14630 A0A556V2G4_14630 2-114 190-302 0.98 0.33 0.98 0.33 0.33 0.97 92.9
1.10.580 MC14630 J4D7V7_14630 20-305 2-457 0.94 0.96 0.9 0.58 0.58 0.83 27.2
3.30.1540 MC14553 A0A6P4K6S1_14553 1-91 52-239 1.0 0.77 0.96 0.37 0.37 0.94 25.5
3.90.740 MC1451 A0A6A7BAD8_1451 3-246 15-248 0.99 0.65 0.11 0.09 0.09 0.0 8.4
3.30.1730 MC14441 A0A2R7SUD2_14441 1-116 1-114 0.83 1.0 0.78 0.95 0.95 0.77 37.9
3.30.1060 MC1434 A0A7W0K964_1434 30-212 10-208 0.86 0.53 0.11 0.07 0.07 0.0 12.6
Legend
  • Agreement between CATH Folds and DPCstruct Metacluster Domains:
  • CATH Fold: CATH fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.