DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

MCID Size Avg. Len. Len. Std Len. Ratio pLDDT Disorder TM-Score lDDT pIdent Pfam Score Pfam Labels
MC14217 18 78.33 4.69 0.06 80.56 0.33 0.86 0.8 31.2 0.0 UNKNOWN
MC14218 6 98.5 6.45 0.07 91.02 0.32 0.77 0.7 29.52 0.0 UNKNOWN
MC14220 11 115.09 4.76 0.04 89.48 0.22 0.78 0.7 20.1 0.0 UNKNOWN
MC14222 19 101.0 12.91 0.13 91.01 0.23 0.83 0.81 39.71 100.0 CL0125
MC14223 51 133.35 30.73 0.23 90.62 0.33 0.84 0.84 31.51 100.0 CL0036
MC14224 5 78.0 7.82 0.1 84.37 0.25 0.72 0.73 26.07 0.0 UNKNOWN
MC14225 11 164.27 20.94 0.13 91.25 0.19 0.85 0.72 29.38 0.0 UNKNOWN
MC14227 17 70.88 3.69 0.05 84.6 0.15 0.88 0.89 61.12 100.0 PF02325
MC14228 9 115.11 11.56 0.1 89.79 0.25 0.82 0.78 40.53 0.0 UNKNOWN
MC14229 10 82.6 7.63 0.09 85.47 0.19 0.88 0.84 50.37 0.0 UNKNOWN
Legend
  • A. Metacluster Structural Properties :
  • MCID: Unique identifier per metacluster.
  • Size: Number of structural domain members.
  • Avg. Len.: Mean domain length of all members (amino acids).
  • Len. Std: Standard deviation of domain lengths.
  • Len. Ratio: Ratio of standard deviation to average domain length.
  • pLDDT: Mean AlphaFold2 confidence score (predicted Local Distance Difference Test) across all members.
  • Disorder: Mean fraction of residues predicted as intrinsically disordered.
  • TM-Score: Mean intra-cluster pairwise alignment Template Modeling score, averaged over all pairs, using the maximum between TM-score normalized by query or target to account for size differences.
  • lDDT: Mean intra-cluster local Distance Difference Test score (local structural similarity).
  • pIdent: Mean intra-cluster sequence similarity (%).
  • B. Pfam Annotations:
  • Pfam Score: Global Pfam Score quantifying the agreement between the metacluster and Pfam domains.
  • Pfam Labels: Assigned Pfam labels (clans or families). Displayed as UNKNOWN (representing 'dark matter') if no Pfam domains are assigned to the metacluster.