DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

MCID Size Avg. Len. Len. Std Len. Ratio pLDDT Disorder TM-Score lDDT pIdent Pfam Score Pfam Labels
MC11186 10 66.5 6.77 0.1 84.59 0.2 0.84 0.79 51.09 0.0 UNKNOWN
MC11187 28 119.43 11.6 0.1 79.73 0.3 0.6 0.63 34.76 0.0 UNKNOWN
MC11189 73 138.12 25.38 0.18 79.04 0.24 0.65 0.59 18.67 45.45 CL0123-CL0237
MC11191 29 151.21 21.18 0.14 67.52 0.75 0.45 0.83 33.67 0.0 UNKNOWN
MC11192 22 645.59 142.39 0.22 76.46 0.22 0.65 0.64 21.74 100.0 PF09773
MC11194 41 136.61 24.15 0.18 82.82 0.26 0.75 0.8 28.27 98.08 CL0063-CL0335
MC11195 19 122.74 23.11 0.19 71.21 0.43 0.44 0.71 33.29 100.0 CL0692
MC11196 7 97.71 13.73 0.14 69.37 0.26 0.73 0.8 48.85 100.0 CL0613
MC11197 11 164.64 12.05 0.07 82.32 0.18 0.77 0.68 22.57 0.0 UNKNOWN
MC11198 5 155.6 8.69 0.06 83.21 0.19 0.67 0.64 23.8 0.0 UNKNOWN
Legend
  • A. Metacluster Structural Properties :
  • MCID: Unique identifier per metacluster.
  • Size: Number of structural domain members.
  • Avg. Len.: Mean domain length of all members (amino acids).
  • Len. Std: Standard deviation of domain lengths.
  • Len. Ratio: Ratio of standard deviation to average domain length.
  • pLDDT: Mean AlphaFold2 confidence score (predicted Local Distance Difference Test) across all members.
  • Disorder: Mean fraction of residues predicted as intrinsically disordered.
  • TM-Score: Mean intra-cluster pairwise alignment Template Modeling score, averaged over all pairs, using the maximum between TM-score normalized by query or target to account for size differences.
  • lDDT: Mean intra-cluster local Distance Difference Test score (local structural similarity).
  • pIdent: Mean intra-cluster sequence similarity (%).
  • B. Pfam Annotations:
  • Pfam Score: Global Pfam Score quantifying the agreement between the metacluster and Pfam domains.
  • Pfam Labels: Assigned Pfam labels (clans or families). Displayed as UNKNOWN (representing 'dark matter') if no Pfam domains are assigned to the metacluster.