DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

CATH Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
3.10.320 MC7726 A0A1H0F0E9_7726 4-73 14-78 0.9 0.42 0.39 0.22 0.22 0.51 7.0
2.30.140 MC7720 Q2LTP6_7720 2-49 13-61 0.92 0.56 0.54 0.36 0.36 0.6 11.7
3.10.330 MC7720 A0A328IIH0_7720 2-44 28-70 0.92 0.43 0.55 0.3 0.3 0.6 19.5
3.40.1170 MC7708 A0A0W7TI51_7708 2-69 3-72 0.94 0.46 0.9 0.44 0.44 0.87 38.5
3.40.1350 MC7708 F2L2L8_7708 4-88 1-85 0.91 1.0 0.9 0.99 0.99 0.95 69.4
3.30.2310 MC7696 A0A849B6W7_7696 6-85 3-150 0.89 0.87 0.69 0.39 0.39 0.63 5.4
1.10.575 MC7688 A0A1R2B0T7_7688 10-240 14-236 0.96 0.68 0.28 0.22 0.22 0.0 12.5
1.20.950 MC7688 A0A7R8CS41_7688 2-167 54-226 0.93 0.49 0.35 0.2 0.2 0.52 10.7
3.90.470 MC7684 A0A7J0EKR2_7684 1-151 50-191 1.0 0.35 0.28 0.14 0.14 0.0 7.9
3.90.228 MC7684 A0A0V1LA69_7684 1-205 105-225 0.98 0.37 0.14 0.1 0.1 0.0 10.7
Legend
  • Agreement between CATH Folds and DPCstruct Metacluster Domains:
  • CATH Fold: CATH fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.