DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

CATH Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
2.100.10 MC7682 A0A3L6SG92_7682 2-130 1-79 0.84 1.0 0.29 0.53 0.53 0.3 14.1
3.20.20 MC7650 A0A1S3JLQ6_7650 5-295 2-294 0.98 0.62 0.88 0.56 0.56 0.77 38.9
1.20.1690 MC7642 A0A3D1VD77_7642 5-104 25-140 0.94 0.69 0.54 0.38 0.38 0.48 16.5
3.10.25 MC7641 A0A328PA43_7641 7-98 1-120 0.93 0.8 0.58 0.42 0.42 0.53 11.7
3.10.300 MC7641 A0A1V3R7M2_7641 7-203 1-177 0.94 1.0 0.81 0.95 0.95 0.78 36.0
1.20.960 MC7637 A0A1A6H9X7_7637 2-65 33-96 0.97 0.54 0.95 0.53 0.53 0.95 96.8
3.90.1420 MC7630 W9RH21_7630 7-155 23-147 0.9 0.54 0.61 0.45 0.45 0.63 17.9
1.10.1090 MC7619 A0A7N2RA79_7619 4-105 20-111 0.96 0.7 0.26 0.22 0.22 0.5 16.3
3.30.370 MC7604 A0A1Q9E3K1_7604 1-76 1-85 0.97 0.32 0.43 0.15 0.15 0.51 12.6
1.20.890 MC7604 A0A2P6V8T2_7604 1-40 17-56 0.89 0.15 0.86 0.15 0.15 0.91 60.0
Legend
  • Agreement between CATH Folds and DPCstruct Metacluster Domains:
  • CATH Fold: CATH fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.