DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

CATH Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
3.30.1370 MC8283 A0A6A4GE88_8283 5-68 1-70 0.94 0.4 0.63 0.29 0.29 0.56 6.9
6.10.140 MC8283 A0A2T6ZSF7_8283 1-37 152-188 1.0 0.17 0.97 0.17 0.17 0.96 67.5
3.30.1890 MC8281 A0A1W2M005_8281 4-138 2-86 0.98 0.88 0.41 0.56 0.56 0.44 9.2
3.90.1170 MC8281 A0A2W6Z6Q6_8281 1-99 3-109 0.92 0.83 0.56 0.49 0.49 0.49 7.4
3.30.230 MC8273 A0A846PH61_8273 5-165 1-161 0.96 1.0 0.94 0.98 0.98 0.91 42.2
2.20.220 MC8272 A0A2T4UJM3_8272 8-61 44-118 0.87 0.62 0.54 0.3 0.3 0.58 10.3
1.10.1220 MC8269 A0A2H0RVR7_8269 1-41 78-118 1.0 0.32 0.93 0.31 0.31 0.96 9.7
3.30.1330 MC8264 A0A2N2JMW1_8264 2-116 1-115 0.99 0.99 0.95 0.95 0.95 0.91 40.5
3.40.47 MC8264 A0A535N2B4_8264 12-182 1-102 0.94 1.0 0.37 0.58 0.58 0.39 11.0
2.90.10 MC8263 A0A7W2JUC9_8263 10-70 38-105 0.87 0.61 0.49 0.35 0.35 0.6 12.6
Legend
  • Agreement between CATH Folds and DPCstruct Metacluster Domains:
  • CATH Fold: CATH fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.