DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

MCID Size Avg. Len. Len. Std Len. Ratio pLDDT Disorder TM-Score lDDT pIdent Pfam Score Pfam Labels
MC24190 64 85.2 10.83 0.13 91.55 0.2 0.78 0.74 29.34 100.0 CL0257
MC24193 43 233.4 48.47 0.21 76.33 0.19 0.48 0.49 19.68 96.97 PF19270-CL0271
MC24194 15 133.33 28.68 0.22 67.73 0.48 0.49 0.74 39.91 0.0 UNKNOWN
MC24201 41 320.05 84.1 0.26 77.51 0.27 0.59 0.65 23.6 100.0 PF04782
MC24203 39 79.59 9.66 0.12 66.5 0.59 0.61 0.83 57.85 100.0 CL0114
MC24204 9 307.78 29.05 0.09 71.2 0.39 0.56 0.8 31.62 0.0 UNKNOWN
MC24206 16 322.12 45.48 0.14 81.58 0.15 0.7 0.83 69.28 0.0 UNKNOWN
MC24207 44 113.32 23.47 0.21 80.58 0.24 0.48 0.75 44.2 68.42 CL0213-CL0029
MC24208 43 76.47 14.51 0.19 79.32 0.37 0.8 0.84 66.27 100.0 CL0004
MC24209 8 95.25 12.56 0.13 76.9 0.26 0.87 0.86 51.7 100.0 CL0255
Legend
  • A. Metacluster Structural Properties :
  • MCID: Unique identifier per metacluster.
  • Size: Number of structural domain members.
  • Avg. Len.: Mean domain length of all members (amino acids).
  • Len. Std: Standard deviation of domain lengths.
  • Len. Ratio: Ratio of standard deviation to average domain length.
  • pLDDT: Mean AlphaFold2 confidence score (predicted Local Distance Difference Test) across all members.
  • Disorder: Mean fraction of residues predicted as intrinsically disordered.
  • TM-Score: Mean intra-cluster pairwise alignment Template Modeling score, averaged over all pairs, using the maximum between TM-score normalized by query or target to account for size differences.
  • lDDT: Mean intra-cluster local Distance Difference Test score (local structural similarity).
  • pIdent: Mean intra-cluster sequence similarity (%).
  • B. Pfam Annotations:
  • Pfam Score: Global Pfam Score quantifying the agreement between the metacluster and Pfam domains.
  • Pfam Labels: Assigned Pfam labels (clans or families). Displayed as UNKNOWN (representing 'dark matter') if no Pfam domains are assigned to the metacluster.