DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

MCID Size Avg. Len. Len. Std Len. Ratio pLDDT Disorder TM-Score lDDT pIdent Pfam Score Pfam Labels
MC30719 27 389.04 65.47 0.17 72.32 0.23 0.4 0.59 22.72 0.0 UNKNOWN
MC30720 4 183.5 16.58 0.09 76.03 0.22 0.66 0.71 36.49 0.0 UNKNOWN
MC30721 11 103.91 13.59 0.13 84.54 0.16 0.55 0.82 45.77 100.0 CL0100
MC30723 5 174.6 22.14 0.13 83.93 0.29 0.51 0.77 29.4 100.0 CL0422
MC30728 16 136.12 17.52 0.13 88.13 0.52 0.8 0.71 43.55 100.0 PF00921
MC30733 10 186.1 29.76 0.16 84.23 0.24 0.55 0.48 16.64 0.0 UNKNOWN
MC30734 28 106.18 13.06 0.12 89.79 0.32 0.87 0.8 42.41 100.0 CL0171
MC30739 17 127.29 10.05 0.08 85.96 0.2 0.83 0.81 37.64 100.0 PF11000
MC30742 100 171.31 21.92 0.13 79.95 0.28 0.54 0.64 18.65 100.0 CL0292
MC30743 91 200.42 28.4 0.14 84.97 0.36 0.56 0.47 15.23 100.0 PF11579
Legend
  • A. Metacluster Structural Properties :
  • MCID: Unique identifier per metacluster.
  • Size: Number of structural domain members.
  • Avg. Len.: Mean domain length of all members (amino acids).
  • Len. Std: Standard deviation of domain lengths.
  • Len. Ratio: Ratio of standard deviation to average domain length.
  • pLDDT: Mean AlphaFold2 confidence score (predicted Local Distance Difference Test) across all members.
  • Disorder: Mean fraction of residues predicted as intrinsically disordered.
  • TM-Score: Mean intra-cluster pairwise alignment Template Modeling score, averaged over all pairs, using the maximum between TM-score normalized by query or target to account for size differences.
  • lDDT: Mean intra-cluster local Distance Difference Test score (local structural similarity).
  • pIdent: Mean intra-cluster sequence similarity (%).
  • B. Pfam Annotations:
  • Pfam Score: Global Pfam Score quantifying the agreement between the metacluster and Pfam domains.
  • Pfam Labels: Assigned Pfam labels (clans or families). Displayed as UNKNOWN (representing 'dark matter') if no Pfam domains are assigned to the metacluster.