DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

CATH Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
1.10.1740 MC6931 A0A7J6Q1K9_6931 4-87 1-135 0.96 0.66 0.88 0.4 0.4 0.82 23.7
3.30.2140 MC6931 A0A4Q3DX63_6931 3-141 11-150 0.8 0.91 0.47 0.53 0.53 0.63 27.9
3.10.620 MC6931 A0A6F8T2Y2_6931 7-164 2-158 0.87 0.94 0.82 0.88 0.88 0.86 60.4
3.90.660 MC6931 A0A267H6J2_6931 24-214 6-148 0.86 0.87 0.17 0.22 0.22 0.0 13.1
1.10.189 MC6927 A0A229NYI9_6927 3-58 2-59 0.89 0.78 0.35 0.31 0.31 0.5 13.7
1.20.810 MC6926 A0A7Z0CUU6_6926 33-215 5-136 0.85 0.86 0.42 0.56 0.56 0.46 10.2
2.10.70 MC6919 A0A3Q1F499_6919 2-34 29-61 0.92 0.28 0.78 0.27 0.27 0.76 30.3
3.90.1180 MC6918 M7B400_6918 15-139 8-125 0.9 0.9 0.35 0.36 0.36 0.0 13.0
3.50.80 MC6918 U3TAV9_6918 1-134 1-134 1.0 0.99 1.0 0.99 0.99 1.0 81.3
1.10.166 MC6902 A0A2S8PCB0_6902 2-63 38-104 0.89 0.36 0.32 0.17 0.17 0.52 14.9
Legend
  • Agreement between CATH Folds and DPCstruct Metacluster Domains:
  • CATH Fold: CATH fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.