DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

CATH Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
3.40.1380 MC7128 E6VZA3_7128 2-127 482-618 0.99 0.22 0.71 0.16 0.16 0.63 18.1
1.20.210 MC7128 A0A136LPJ7_7128 17-530 8-381 0.97 0.94 0.11 0.13 0.13 0.0 11.0
1.20.190 MC7128 A0A7V4MT29_7128 4-205 242-406 0.93 0.25 0.49 0.18 0.18 0.54 11.7
1.10.620 MC7128 A0A6J6JUP5_7128 37-340 2-359 0.89 0.98 0.12 0.12 0.12 0.0 12.0
1.10.1300 MC7128 A0A811NZI7_7128 25-320 19-337 0.92 0.92 0.15 0.14 0.14 0.0 8.2
2.30.39 MC7125 A0A7J7K0C0_7125 1-130 42-183 1.0 0.38 0.29 0.13 0.13 0.0 15.3
1.20.1150 MC7112 A0A183EZR1_7112 1-90 14-106 0.93 0.76 0.34 0.28 0.28 0.52 13.0
1.10.3390 MC7107 A0A6F9DQS0_7107 1-86 28-115 0.92 0.52 0.3 0.2 0.2 0.69 15.3
6.20.250 MC7095 A0A2G7GP03_7095 2-48 113-165 0.98 0.23 0.52 0.16 0.16 0.62 15.0
4.10.1060 MC7089 A0A7J8DD91_7089 2-47 13-84 0.98 0.53 0.56 0.21 0.21 0.71 19.4
Legend
  • Agreement between CATH Folds and DPCstruct Metacluster Domains:
  • CATH Fold: CATH fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.