DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

CATH Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
3.90.440 MC814 A0A1S3IG29_814 8-96 1-103 0.86 0.18 0.85 0.15 0.15 0.88 53.3
6.20.50 MC8133 A0A673MLC0_8133 1-37 59-112 1.0 0.47 0.9 0.31 0.31 0.89 29.6
3.30.1680 MC8133 A0A212CIL6_8133 2-59 24-81 0.98 0.45 0.95 0.44 0.44 0.94 81.0
3.40.1550 MC8131 A0A1V6AAJ1_8131 1-182 15-204 0.98 0.55 0.85 0.48 0.48 0.73 24.7
3.30.900 MC8131 A0A3Q7PM76_8131 1-183 5-189 1.0 0.71 0.99 0.69 0.69 0.95 98.3
1.20.1330 MC8118 A0A4Z0Q354_8118 1-130 1-121 0.82 0.94 0.44 0.51 0.51 0.49 11.8
1.20.1390 MC8111 A0A6V7XAT9_8111 6-65 9-68 0.84 0.86 0.71 0.72 0.72 0.65 25.0
1.20.80 MC8107 A0A8B6GD33_8107 3-61 59-116 0.95 0.5 0.85 0.47 0.47 0.79 28.8
3.40.30 MC8097 A0A834H2B6_8097 3-144 241-397 0.98 0.35 0.76 0.27 0.27 0.61 17.7
4.10.40 MC8091 G1T6C3_8091 1-41 41-81 1.0 0.51 0.87 0.47 0.47 0.88 100.0
Legend
  • Agreement between CATH Folds and DPCstruct Metacluster Domains:
  • CATH Fold: CATH fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.