DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

CATH Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
3.10.450 MC7179 P0CL71_7179 1-148 27-174 0.99 0.85 0.98 0.84 0.84 0.98 84.4
1.20.200 MC7169 A0A1I7XH89_7169 1-234 15-172 0.94 0.91 0.44 0.59 0.59 0.49 8.8
1.20.120 MC7169 A0A2D4FRX4_7169 10-174 2-166 0.95 0.99 0.93 0.98 0.98 0.94 98.1
1.20.1290 MC7165 F6DJC0_7165 4-86 1-76 0.96 0.97 0.59 0.64 0.64 0.65 26.5
3.40.710 MC7162 A0A812JYV8_7162 49-250 332-659 0.81 0.43 0.21 0.09 0.09 0.0 12.0
3.40.1020 MC7162 A0A3D3VQJ5_7162 3-166 303-482 0.89 0.37 0.59 0.24 0.24 0.51 11.0
3.30.2130 MC7162 A0A3D3VQJ5_7162 7-128 303-481 0.86 0.37 0.37 0.12 0.12 0.54 11.7
1.10.110 MC7162 A0A4P0UAT0_7162 1-85 225-312 0.99 0.12 0.82 0.11 0.11 0.71 18.1
1.10.3210 MC7162 A0A7V2F3S6_7162 34-169 328-482 0.8 0.21 0.48 0.12 0.12 0.54 20.1
1.10.3090 MC7162 A0A7C5C778_7162 5-200 23-266 0.86 0.44 0.66 0.3 0.3 0.57 16.1
Legend
  • Agreement between CATH Folds and DPCstruct Metacluster Domains:
  • CATH Fold: CATH fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.