DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

CATH Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
3.40.525 MC8570 A0A6P4TKL6_8570 29-194 24-160 0.86 0.78 0.2 0.22 0.22 0.0 13.5
3.40.190 MC8570 A0A1N6PLK7_8570 5-118 1-107 0.95 0.97 0.51 0.54 0.54 0.42 17.0
3.90.190 MC8570 A0A6S7BEW2_8570 25-146 4-145 0.84 0.89 0.35 0.33 0.33 0.0 8.6
3.40.1080 MC8570 A0A411WW61_8570 22-142 1-101 0.81 0.98 0.38 0.51 0.51 0.4 8.5
3.40.1400 MC8570 A0A372IP25_8570 1-128 1-99 0.81 0.97 0.46 0.65 0.65 0.46 11.7
3.40.640 MC8570 M6BZE9_8570 32-196 5-135 0.84 0.97 0.41 0.56 0.56 0.42 10.7
3.40.91 MC8570 A0A536VYV9_8570 1-114 11-86 0.88 0.79 0.3 0.39 0.39 0.53 13.9
3.40.50 MC8570 A0A377BWL9_8570 1-143 4-146 1.0 0.94 1.0 0.93 0.93 1.0 100.0
3.40.250 MC8570 F7RYM5_8570 1-80 32-106 1.0 0.56 0.54 0.35 0.35 0.58 14.6
3.30.365 MC8570 A0A350CSY2_8570 1-75 3-77 0.81 0.49 0.8 0.48 0.48 0.86 74.6
Legend
  • Agreement between CATH Folds and DPCstruct Metacluster Domains:
  • CATH Fold: CATH fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.