DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

CATH Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
3.40.120 MC8570 A0A7V8FJA4_8570 2-69 9-67 0.84 0.48 0.43 0.3 0.3 0.51 13.5
3.40.1010 MC8570 A0A534UEE4_8570 3-95 5-97 0.93 0.63 0.6 0.44 0.44 0.53 10.3
3.30.870 MC8570 A0A378WMZ1_8570 14-143 2-136 0.91 0.68 0.75 0.55 0.55 0.68 13.8
3.40.1050 MC8570 A7BMD6_8570 13-152 1-89 0.83 0.99 0.33 0.51 0.51 0.39 10.0
3.90.550 MC8570 A0A2T0S5F5_8570 13-251 1-166 0.85 0.92 0.18 0.26 0.26 0.0 17.3
3.40.1190 MC8570 A0A7W1JAL0_8570 4-217 2-133 0.92 0.98 0.39 0.6 0.6 0.38 9.0
3.40.800 MC8570 A0A354I6J5_8570 2-329 4-203 0.92 0.95 0.2 0.28 0.28 0.0 8.8
3.40.470 MC8570 A0A7C5J3G8_8570 14-188 3-109 0.89 0.95 0.34 0.52 0.52 0.37 7.9
3.40.220 MC8570 A0A7C8RAB2_8570 22-155 1-99 0.8 1.0 0.37 0.54 0.54 0.34 9.5
3.40.35 MC8570 A0A1Y1IPW7_8570 25-147 8-112 0.8 0.94 0.41 0.52 0.52 0.39 12.3
Legend
  • Agreement between CATH Folds and DPCstruct Metacluster Domains:
  • CATH Fold: CATH fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.